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This approach is approximate at best, as it propagates the inherent error present in the binary reactivity ratio estimates, overlooks the effect of the interactions between all three monomers on their reactivity towards each other and is not at all reliable for predicting ternary compositions. This work exposed the fact that the model suffers from symmetry issues; final results depend on the arbitrary choice of different combinations of copolymer mole fractions into the parameter estimation scheme.

EVM considers error in all terms, so using a design of experiments technique within the EVM context helps to account for the error in both the independent variables (feed compositions) and the dependent variables (terpolymer compositions). To help visualize the location of the optimal feed compositions for this system, Figure 2 combines the suboptimal regions (shaded areas) as well as the three optimal points located close to or inside these regions.